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Pathophysiology of hair greying The natural coloration of hair is a multi-step process

HIF-1 orchestrates this adaptation under low oxygen tension, transcriptionally activating glycolysis-associated genes such as glucose transporters (GLUT1/3), glycolytic enzymes (HK1/2, ENO1, PGK1, PKM2), and lactate dehydrogenase A (LDHA), thereby shifting energy production from oxidative phosphorylation to aerobic glycolysis (9496)

Incubations with primary antibody (anti-Cystatin C, Sigma, HPA013143, used at 1:100 dilution) were performed at room temperature for 30 min

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